당뇨병 환자의 이하선 타액내 단백질의 다형현상에 대한 연구
A Study on the Polymorphisms in Parotid Salivary Proteins of the Patients with Diabetes Mellitus
안종모, 윤창륙,
소속 상세정보
안종모 ( Ahn Jong-Mo ) - 조선대학교 치과대학 구강내과학교실
윤창륙 ( Yoon Chang-Lyuk ) - 조선대학교 치과대학 구강내과학교실
KMID : 0353319920160020473
Abstract
The purpose of this study was to evaluate the polymorphisms in parotid salivary proteins of the patients with diabetes mellitus.
Saliva form the parotid glands was collected form 94 healthy Korean adults who were live in Kwang-ju and form 33 diabetes mellitus patient who had more than 140mg/dl of fasting-blood sugar for one week.
Diabetes mellitus patient group was subdivided to insulin dependent diabetes mellitus(IDDM) and non-insulin dependent diabetes mellitus(NIDDM).
In the saliva collected from the parotid glands, parotid acidic protein(Pa), proline-rich protein(Pr) and double band protein(Db) were analyzed to evaluate the distribution of phenotype using alkaline slab polyacrylamide gel electrophoresis.
@ES Results were as follows:
@EN 1. The parotid acidic protein(Pa) was found more frequently in the diabetes mellitus patient group than in the control group, but the difference was not statistically significant.
2. The Pr(1-2) type was found more frequently in the control group, but the Pr(1-1) and Pr(2-2) type were found more frequently in the diabetes mellitus patient group and the difference of phenotypic distribution was statistically significant
between
the two groups (P<0.05)
3. The parotid acidic protein(Pa) and Pr(1-2) type were found more frequently in the non-insulin dependent diabetes mellitus(NIDDM) patients than in the insulin dependent diabetes mellitus patients, thought the difference was not statistically
significant.
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